When announcing the USDA deregulation decision without conditions, Agriculture Secretary Tom Vilsack noted that alfalfa industry stakeholders would be working together to keep Roundup Ready genetics from entering the organic or non-genetically modified alfalfa seed streams. The National Alfalfa and Forage Alliance has worked with Monsanto, Forage Genetics International and the alfalfa industry to craft specific stakeholder agreements dealing with isolation distances to prevent cross-pollination.

Roundup Ready alfalfa was initially taken off the market after preliminary and permanent injunctions were enacted in 2007. This action was taken in response to a lawsuit claiming USDA was in error when the agency deregulated Roundup Ready alfalfa without having completed an EIS.